abstract：:In recent years, early intervention services have attempted to identify people with a first episode of psychosis as early as possible, reducing the duration of untreated psychosis and changing the timing of delivery of interventions. The logic of early intervention is based partly on accessing people in a more treatme...

journal_title：Schizophrenia research

authors： Francey SM,Nelson B,Thompson A,Parker AG,Kerr M,Macneil C,Fraser R,Hughes F,Crisp K,Harrigan S,Wood SJ,Berk M,McGorry PD

更新日期：2010-06-01 00:00:00

abstract：:A motivation is a telling hallmark of negative symptomatology in schizophrenia, and it impacts nearly every facet of behavior, including inclination to attempt the difficult cognitive tasks involved in cognitive remediation therapy. Experiences of external reward, reinforcement, and hedonic anticipatory enjoyment are ...

journal_title：Schizophrenia research

authors： Choi J,Medalia A

更新日期：2010-05-01 00:00:00

abstract：:Developmental instability (DI) refers to the inability of the developing brain to buffer the effects of genetic and environmental insults. This concept has been invoked to better understand how fetal brain development goes awry in schizophrenia and related spectrum disorders. This study examined one marker of DI, mino...

journal_title：Schizophrenia research

authors： Blanchard JJ,Aghevli M,Wilson A,Sargeant M

更新日期：2010-05-01 00:00:00

abstract：:Polydipsia and water intoxication (PWI) are relatively frequent among schizophrenic subjects, particularly in institutional settings and may lead to severe complications. However, little is known on their association with other characteristics of psychosis. Hence, we took advantage of a cohort of 114 subjects extensiv...

journal_title：Schizophrenia research

authors： Poirier S,Legris G,Tremblay P,Michea R,Viau-Guay L,Mérette C,Bouchard RH,Maziade M,Roy MA

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:We examined cognitive deficits before and after onset of schizophrenia in a longitudinal study that: 1) covers a long time interval; 2) minimizes test unreliability by including the identical measure at both childhood and post-onset cognitive assessments; and 3) minimizes bias by utilizing a population-based...

journal_title：Schizophrenia research

authors： Kremen WS,Vinogradov S,Poole JH,Schaefer CA,Deicken RF,Factor-Litvak P,Brown AS

更新日期：2010-05-01 00:00:00

abstract：:Few studies have investigated the relationships between static, elementary neurocognitive functions, dynamic measures of learning potential and functional status in schizophrenia, despite the putative role of learning potential in models of the relationship between static neurocognitive function and functional status ...

journal_title：Schizophrenia research

authors： Kurtz MM,Jeffrey SB,Rose J

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:While poor premorbid functioning is associated with poorer outcomes in psychotic illnesses, little is known about whether it is also a risk factor for suicide attempts. OBJECTIVE:The current study examined the association of premorbid functioning and suicide attempts in a county-wide cohort of first-admissi...

journal_title：Schizophrenia research

authors： Bakst S,Rabinowitz J,Bromet EJ

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Little is known about the effects of antipsychotic medications on gray matter (GM) in schizophrenia. Although clozapine remains the most effective antipsychotic medication in treatment-refractory cases, it is unknown whether it has a differential effect on GM development. METHODS:In an exploratory analysis,...

journal_title：Schizophrenia research

authors： Mattai A,Chavez A,Greenstein D,Clasen L,Bakalar J,Stidd R,Rapoport J,Gogtay N

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Alterations in the inhibitory circuitry of the dorsolateral prefrontal cortex (DLPFC) in schizophrenia include reduced expression of the messenger RNA (mRNA) for somatostatin (SST), a neuropeptide present in a subpopulation of gamma-aminobutyric acid (GABA) neurons. Neuropeptide Y (NPY) is expressed in a sub...

journal_title：Schizophrenia research

authors： Morris HM,Stopczynski RE,Lewis DA

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Genetic factors are important in the aetiology of psychotic disorders, but it is unclear how far they influence aspects of illness history within psychoses. AIMS:To investigate the extent, and type of familial aggregation for a range of illness history variables in psychosis. METHODS:Two-hundred-and-twenty...

journal_title：Schizophrenia research

authors： Allan CL,Cardno AG,Rijsdijk FV,Kalidindi S,Farmer A,Murray RM,McGuffin P

更新日期：2009-12-01 00:00:00

abstract：:Patients with schizophrenia exhibit impairments in prepulse inhibition (PPI) of the startle response. Available data suggest that atypical antipsychotics may be more effective than typical antipsychotics in improving PPI deficits in schizophrenia. However, previous studies have used between-subjects rather than longit...

journal_title：Schizophrenia research

authors： Martinez-Gras I,Rubio G,del Manzano BA,Rodriguez-Jimenez R,Garcia-Sanchez F,Bagney A,Leza JC,Borrell J

更新日期：2009-12-01 00:00:00

abstract：:Numerous studies have described attenuated event-related potential (ERP) component amplitudes in schizophrenia (e.g., P300, Mismatch Negativity (MMN), Error Negativity/Error-Related Negativity (Ne/ERN)). Functional magnetic resonance imaging (fMRI) studies have typically shown decreased recruitment of diverse brain ar...

journal_title：Schizophrenia research

authors： Bates AT,Kiehl KA,Laurens KR,Liddle PF

更新日期：2009-12-01 00:00:00

abstract：:Patients with schizophrenia often exhibit structural brain abnormalities, as well as neurological soft signs (NSS), consistent with its conceptualization as a neurodevelopmental disorder. NSS are mild, presumably nonlocalizing, neurological impairments that are inferred from performance deficits in domains such as sen...

journal_title：Schizophrenia research

authors： Kaczorowski JA,Barrantes-Vidal N,Kwapil TR

更新日期：2009-12-01 00:00:00

abstract：:Cigarette smoking expectancies are systematically related to intention to quit smoking in adult smokers without psychiatric illness, but little is known about these relationships in smokers with serious mental illness. In this study, we compared positive and negative smoking expectancies, and examined relationships be...

journal_title：Schizophrenia research

authors： Tidey JW,Rohsenow DJ

更新日期：2009-12-01 00:00:00

abstract：:Verbal dichotic listening performance was examined in 42 right-handed men and women with DSM-IV-defined schizotypal personality disorder (SPD) and 68 right-handed controls. As expected, both male and female control groups showed a right ear advantage on a verbal dichotic listening task. Although SPD subjects in genera...

journal_title：Schizophrenia research

authors： Voglmaier MM,Seidman LJ,Niznikiewicz MA,Madan A,Dickey CC,Shenton ME,McCarley RW

更新日期：2009-12-01 00:00:00

abstract：:The etiologic factors underlying schizophrenia have been conceptualized as reflecting two largely genetic components - those unique to schizophrenia and those representing vulnerability to neurodevelopmental deviation in general. The Developmental Instability (DI) approach suggests that the latter can be indexed by mi...

journal_title：Schizophrenia research

authors： Euler M,Thoma RJ,Gangestad SW,Cañive JM,Yeo RA

更新日期：2009-11-01 00:00:00

abstract：:Previous diffusion tensor imaging (DTI) studies have shown structural abnormalities of the cingulum bundle (CB) in patients with schizophrenia. However, regional specificity and functional relevance of the pregenual and dorsal CB subdivisions has not been fully studied. In the current study, 31 patients with schizophr...

journal_title：Schizophrenia research

authors： Takei K,Yamasue H,Abe O,Yamada H,Inoue H,Suga M,Muroi M,Sasaki H,Aoki S,Kasai K

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Neuroimaging findings implicate bilateral superior temporal regions in the genesis of auditory-verbal hallucinations (AVH). This study aimed to investigate whether 1 Hz repetitive transcranial magnetic stimulation (rTMS) of the bilateral temporo-parietal region would lead to increased effectiveness in the ma...

journal_title：Schizophrenia research

authors： Vercammen A,Knegtering H,Bruggeman R,Westenbroek HM,Jenner JA,Slooff CJ,Wunderink L,Aleman A

更新日期：2009-10-01 00:00:00

abstract：:Healthy siblings of schizophrenia patients have an almost 9-fold higher risk for developing the illness than the general population. Disruption of white matter (WM) integrity as indicated by reduced fractional anisotropy (FA) derived from diffusion tensor imaging (DTI), is believed to be the key substrate of schizophr...

journal_title：Schizophrenia research

authors： Hao Y,Yan Q,Liu H,Xu L,Xue Z,Song X,Kaneko Y,Jiang T,Liu Z,Shan B

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Decreased callosal size and anisotropy have been described in schizophrenia patients but their longitudinal progression remains poorly understood. METHODS:We performed diffusion-tensor and structural magnetic resonance imaging at baseline and at follow-up four years later in 49 chronic schizophrenia patient...

journal_title：Schizophrenia research

authors： Mitelman SA,Nikiforova YK,Canfield EL,Hazlett EA,Brickman AM,Shihabuddin L,Buchsbaum MS

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVES:Gender differences in psychotic disorder have been observed in terms of illness onset and course; however, past research has been limited by inconsistencies between studies and the lack of epidemiological representative of samples assessed. Thus, the aim of this study was to elucidate gender differences in a...

journal_title：Schizophrenia research

authors： Cotton SM,Lambert M,Schimmelmann BG,Foley DL,Morley KI,McGorry PD,Conus P

更新日期：2009-10-01 00:00:00

abstract：:The SELENBP1 gene previously was found to be up-regulated in microarray analysis of both peripheral blood cell and brain tissue samples from schizophrenia patients. Quantitative PCR analysis subsequently corroborated the altered expression of SELENBP1 in schizophrenia brain tissue samples from the Stanley Array Correc...

journal_title：Schizophrenia research

authors： Kanazawa T,Glatt SJ,Faraone SV,Hwu HG,Yoneda H,Tsuang MT

更新日期：2009-09-01 00:00:00

abstract：:Prior studies of mRNA expression, protein expression, and pathway metabolite levels have implicated dysregulation of the kynurenine pathway in the etiology of schizophrenia and bipolar disorder. Here we investigate whether genes involved in kynurenine pathway regulation might interact with genes that respond to kynure...

journal_title：Schizophrenia research

authors： Miller CL,Murakami P,Ruczinski I,Ross RG,Sinkus M,Sullivan B,Leonard S

更新日期：2009-09-01 00:00:00

abstract：:A recent systematic review concluded that cannabis use increases risk of psychotic outcomes independently of confounding and transient intoxication effects. Furthermore, a model of the association between cannabis use and schizophrenia indicated that the incidence and prevalence of schizophrenia would increase from 19...

journal_title：Schizophrenia research

authors： Frisher M,Crome I,Martino O,Croft P

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:The onset of psychosis is thought to be preceded by neurodevelopmental changes in the brain. However, the timing of these changes has not been established. We investigated structural brain changes in a sample of young adolescents (12-18 years) at ultra high-risk for psychosis (UHR). METHODS:Structural MRI da...

journal_title：Schizophrenia research

authors： Ziermans TB,Durston S,Sprong M,Nederveen H,van Haren NE,Schnack HG,Lahuis BE,Schothorst PF,van Engeland H

更新日期：2009-07-01 00:00:00

abstract：:A randomised trial was conducted in order to estimate the clinical and cost-effectiveness of social recovery orientated cognitive behavioural therapy (SRCBT) for people diagnosed with psychosis, compared to case management alone (CMA). The mean incremental health and social care cost, and the mean incremental quality ...

journal_title：Schizophrenia research

authors： Barton GR,Hodgekins J,Mugford M,Jones PB,Croudace T,Fowler D

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Superior temporal gyrus (STG/BA22) volume is reduced in schizophrenia and to a milder degree in schizotypal personality disorder (SPD), representing a less severe disorder in the schizophrenia spectrum. SPD and Borderline personality disorder (BPD) are severe personality disorders characterized by social and...

journal_title：Schizophrenia research

authors： Goldstein KE,Hazlett EA,New AS,Haznedar MM,Newmark RE,Zelmanova Y,Passarelli V,Weinstein SR,Canfield EL,Meyerson DA,Tang CY,Buchsbaum MS,Siever LJ

更新日期：2009-07-01 00:00:00

abstract：:In 1990 a satellite session of the American College of Neuropsychopharmacology (ACNP) Annual Meeting was held that focused on the question of whether progressive changes in brain structure occur in schizophrenia and this session raised considerable controversy. Eighteen years later, on December 12, 2008, after much da...

journal_title：Schizophrenia research

authors： Borgwardt SJ,Dickey C,Hulshoff Pol H,Whitford TJ,DeLisi LE

更新日期：2009-07-01 00:00:00

abstract：:Schizophrenia is associated with subtle developmental compromise, but the degree to which this is also associated with heritability and genetic risk is uncertain. The goal of the current study was to investigate the childhood, adolescent, and early adulthood social and academic function of patients with schizophrenia,...

journal_title：Schizophrenia research

authors： Shapiro DI,Marenco S,Spoor EH,Egan MF,Weinberger DR,Gold JM

更新日期：2009-07-01 00:00:00

abstract：:NRG1 is one of the most researched genes associated with schizophrenia. Although three meta-analyses in this area have been published, the results have been inconclusive and even conflicting. Family based studies can be problematical due to the difficulty of synthesizing them with case-control studies. Heterogeneity i...

journal_title：Schizophrenia research

authors： Gong YG,Wu CN,Xing QH,Zhao XZ,Zhu J,He L

更新日期：2009-06-01 00:00:00

abstract：:Morphologic abnormalities of the insular cortex have been described in psychotic disorders such as schizophrenia, but it remains unclear whether these changes predate the onset of psychosis or develop progressively over the course of illness. In this study, we used magnetic resonance imaging to investigate the gray ma...

journal_title：Schizophrenia research

authors： Takahashi T,Wood SJ,Yung AR,Phillips LJ,Soulsby B,McGorry PD,Tanino R,Zhou SY,Suzuki M,Velakoulis D,Pantelis C

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Cognitive remediation therapy (CRT) has proven to be effective in treating cognitive deficits in schizophrenia. The current study aimed to assess the efficacy of CRT on psychotic symptoms and cognitive complaints. METHODS:We contrasted the changes in symptoms and cognitive complaints in patients with schizo...

journal_title：Schizophrenia research

authors： Lecardeur L,Stip E,Giguere M,Blouin G,Rodriguez JP,Champagne-Lavau M

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:To examine the effect of diagnosis, mood state, and anxiety on subjective wellbeing in patients with affective and non-affective psychotic disorders treated with quetiapine IR. METHODS:2175 patients with schizophrenia-spectrum (SZ, n=1681), schizoaffective (SA, n=249), and bipolar disorder (BPD, n=245) were ...

journal_title：Schizophrenia research

authors： Lambert M,Naber D,Karow A,Huber CG,Köhler J,Heymann J,Schimmelmann BG

更新日期：2009-05-01 00:00:00

abstract：:Stigma can be a major stressor for individuals with schizophrenia and other mental illnesses. It is unclear, however, why some stigmatized individuals appraise stigma as more stressful, while others feel they can cope with the potential harm posed by public prejudice. We tested the hypothesis that the level of perceiv...

journal_title：Schizophrenia research

authors： Rüsch N,Corrigan PW,Wassel A,Michaels P,Olschewski M,Wilkniss S,Batia K

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Clozapine is the drug of choice for patients with unsatisfactory response to routine antipsychotic treatment. Polypharmacy is widely used among patients having clozapine-resistant schizophrenia, although no solid evidence exists for any effective augmentation therapy for this patient population. We aimed to ...

journal_title：Schizophrenia research

authors： Tiihonen J,Wahlbeck K,Kiviniemi V

更新日期：2009-04-01 00:00:00

abstract：:The search for genes conferring liability for schizophrenia may be aided by the identification of endophenotypes. Response selection is a heritable cognitive function that is impaired in patients with schizophrenia and their unaffected siblings. The abnormalities in cerebral function that presumably underlie the defic...

journal_title：Schizophrenia research

authors： Woodward ND,Waldie B,Rogers B,Tibbo P,Seres P,Purdon SE

更新日期：2009-04-01 00:00:00

abstract：:Diminished expressivity is a characteristic feature of schizophrenia-spectrum pathology. However, attempts to elucidate the neurobiological underpinnings of diminished expressivity have yielded limited information. The present study posited that diminished expressivity was associated with a right, but not left-hemisph...

journal_title：Schizophrenia research

authors： Cohen AS,Iglesias B,Minor KS

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:Clozapine is associated with significant weight gain. However, it is still debatable whether the majority of weight gain occurs in the early phase of treatment or if weight gain is a persistent side effect. The inconsistent results in previous outpatient studies may be due to many confounding factors, such as...

journal_title：Schizophrenia research

authors： Bai YM,Chen JY,Chen TT,Lin CY,Chou P,Su TP,Lin CC

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Noncompliance is common in patients with schizophrenia and can have serious consequences; therefore research of the variables associated with noncompliance is a priority. Although the MEMS device is regarded as the "reference standard" for evaluating compliance, it has been used in very few published studies...

journal_title：Schizophrenia research

authors： Acosta FJ,Bosch E,Sarmiento G,Juanes N,Caballero-Hidalgo A,Mayans T

更新日期：2009-02-01 00:00:00

abstract：:Studies defining the course and outcome of individuals experiencing their first episode (FE) of psychosis generally report an improvement in symptoms and functioning. Today, many FE patients are treated in specialized early psychosis programs. Little is known what happens to these individuals after discharge from thes...

journal_title：Schizophrenia research

authors： Addington J,Addington D

更新日期：2008-12-01 00:00:00